![]() The global market for DNA sequencing is predicted to grow from $15.7 billion in 2021 to $37.7 billion by 2026. And so that is what will be used throughout this guide.Ī brief history of NGS The DNA sequencing landscape Nevertheless, NGS is still the most common terminology that is used to refer to sequencing platforms. Moreover, as sequencing technologies evolve, it could be argued that they are no longer ‘a next generation of sequencing’, but instead, that they are literally sequencing in parallel – hence MPS. Therefore, MPS is clearly separate from the classical Sanger sequencing. Some believe that using MPS to categorize sequencing technologies is more appropriate than NGS because the generations differentiate between short-read and long-read sequencing. Furthermore, third-generation NGS is sometimes called second-generation MPS. The uncertainty arises when discussing second-generation NGS, which is based on pyrosequencing or pH change detection, as it can also be described as first-generation massively parallel sequencing (MPS). First-generation NGS platforms are easy to define because they are based on Sanger sequencing. The terminology used to describe different sequencing platforms can sometimes be confusing, probably due to the fact that NGS has evolved so rapidly over the last few decades. Join David Smith (Mayo Clinic), Shawn Baker (SanDiegOmics) and Tiffany Boughtwood (Australian Genomics) as they discuss how the upcoming shifts within the NGS market could affect genomics research in the future and what impact it may have on healthcare around the world: Exploring the Current Sequencing Landscape What is Massively Parallel Sequencing? *This page was updated on to include some of the recent big announcements made by the likes of Ultima Genomics, PacBio and Illumina. It also underpins the emerging field of liquid biopsy. ![]() DNA sequencing is a booming business because it has become an integral process in many areas of clinical diagnostics. The sequencing industry has grown tremendously since the Human Genome Project’s rough draft was completed and the challenge of completing the $1,000 whole genome was proposed. ![]() Today, there are several DNA sequencing companies that market either second- or third-generation NGS technologies. Perhaps the biggest advance that NGS offered was the ability to produce a huge amount of data, alongside its ability to provide a highly efficient, rapid, low-cost and accurate approach to DNA sequencing, beyond the reach of traditional Sanger methods. NGS became available at the beginning of the 21 st century. Since then, sequencing platforms have made considerable progress and every transformation has led to a huge shift towards furthering genome research, clinical disease research and drug development. It has been over 30 years since the first generation of DNA sequencing technology was developed in 1977.
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